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KMID : 1189420020150010315
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2002 Volume.15 No. 1 p.315 ~ p.335
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The Study On The Effect Of Chungsang bangpungtang and Lonicerae Flos, Coicis Semen (CBTLC) On Acnes
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Hong Seok-Hun
Roh Seok-Sun
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Abstract
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This study was carried out to prove the effects of CBTLC on the 5α-reductase inhibition, the sterilizing power for Propionibactrium acnes, the cytotoxicity of human monocyte, the inhibition for prosta-glandins(PGE2), Interleukins(IL-1β) and TNF-α in inflammation, and the size of Hamster ear sebaceous gland concerned with Acnes. The result were obtained as follows : 1. On the 5α-reductase inhibition of CBTLC in vitro, An undiluted solution of CBTLC was 71% inhibition on 5α-reductase and 1/10 diluted solution of CBTLC was 20% inhibition on 5α-reductase. 2. On the sterilizing power for Propionibactrium acnes concerned in Acnes, an undiluted solution and 1/10 diluted solution of CBTLC formed 12mm clear zone diameters. 3. CBTLC was showed the cytotoxicity of human monocyte in 0.08% and 0.12% of CBTLC. 4. 0.01% and 0.04% of CBTLC inhibited the production of prostaglandins(PGE2) in the human monocyte stimulated with P. acnes LPS. 5. 0.08% and downward of GMHBS inhibited the production of interleukins(lL-1β) in the human monocyte stimulated with P. acnes LPS. 6. 0.08% and 0.12% of GMHBS inhihited the production of TNF-α in the human monocyte stimulated with P. acnes LPS. 7. As the antiandrogenic compound, CBTLC was used in hamster ears with topical application. CBTLC was diminished slightly on the size of hamster ears sebaceous gland.
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